Early Effects of Severe Phosphorus Burns on Gastric Mucosa Functions in Rats / 第三军医大学学报

ABSTRACT

In order to study the mechanism of the barrier functional impairment-of gastric mucosa after burus, phosphorus or napalm 30% TBSA Ⅲ? burns was inflicted to rats and the osmolarity of hydrogen and chlorine ions of their gastric lavage fluid was determined. It was found the concentrations of the 2 ions in the lavage fluid decreased immediately after burn injury, reached the lowest point in the 5th hour postburn, and did not return to its preburn level even in the 72nd hour postburn.It is considered by the authors that the lowering of hydrogen and chlorine ions in the gastric lavage fluid after burns results from the reversed diffusion of the ions into the gastric mucosa since the stress reaction of the organism towards severe burns can impair the barrier function of the gastric musosa and the increase of hydrogen ions in gastric mucosa can aggravate the function impairment. In addition, phosphorus is a cytoplasm toxic. It can be rapidly absorbed through the cutaneous tissue of the burned area and carried to the gastric mucosa to intensify the mucosal lesion.