PATHOLOGICAL OBSERVATIONS ON ACUTE AND SUBACUTE TOXICITY OF PHOTOCARCINORIN(PsD-OO7)IN DOGS / 第二军医大学学报
Academic Journal of Second Military Medical University
;
(12)1982.
Artículo
en Chino
| WPRIM
| ID: wpr-549758
ABSTRACT
Preclinical toxicology of PsD-007(a new photosensitizer prepared in our coll-ege)was studied.Pathological observations were performed on major organs of the toxic dogs including liver, kidneys, myocardium, lungs, spleen, stomach, intestine, mesenteric lymph nodes, urinary bladder, prostata, testes, ovary, adrenals, pituitary gland, thyroid and brain.Focal balloning degeneration of hepatic cells occurred in lower dose groups, and degeneration and necrosis of hepatocytes and proximal convoluted tubular epithelial cells of kidney, and edema of brain in higher dose groups were observed in acute toxicity testing.The hepatocytes were normal, but hyperplasia, swelling and vacuoles within the cytoplasm of the Kupffers cells in liver, necrosis of tubules of kidney and edema of brain in higher dose groups were found in subacute testing. These damages were reversible within 4 weeks except in higher dose groups, and their morphologic severity was dose-related.The results show that the liver and kidney may be the main target organs of toxicity of PsD, and the detections of hepatic and renal functions may be useful to guard against its toxic effects during clinical use.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Academic Journal of Second Military Medical University
Año:
1982
Tipo del documento:
Artículo
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