EFFECT OF SINOMENINE ON THE ISOLATED SUPERIOR CERVICAL GANGLIA OF RABBITS / 中国药理学通报

ABSTRACT

The effect of Sin on the transmission of the impulses through isolated rabbit superior cervical sympathetic ganglia in comparison with that of curare by the sucrose - gap method was studied.Inhibi -tory effect of Sin on the action potential was dose-dependent but no effect on the excitability and conductivity of preganglionic nerves. The ID50 of Sin and curare were 1.2 mM and 0.2 mM, respectively. The effect of Sin was reduced in high Ca2+ concentration solution, and enhanced under Ca2+ free solution. Neostigmine antagonized the effect of Sin.