EFFECT OF IRON DEFSCIENCY ON SODIUM, POTASSIUM-ADENOSSNE TRIPHOSPHATASE IN RAT ERYTHROCYTE MEMBRANES / 第二军医大学学报

ABSTRACT

To study the effect of iron deficiency (ID)on crythrocyte membrane proteins, an investigation of the activity and site of Na+-K+-ATPase in crythrocyte membrane of rats with iron deficient anemia (IDA) was conducted. It was found that changes of the enzyme activity had various ciiaracteristics as ID course went on, and there was no difference in the numbers of 3H-ouabain binding sites (R0) between IDA rats and controls. In contrast to the controls, Na+-K+- ATPase activity of IDA rats showed no relation with R0, suggesting a primary association of the abnormalized activity of the enzyme with its molecular state in ID erythrocyte membrane which could be affected by the surroundings of cell metabolism and spatial structure.