CLINICAL CHARACTERISTICS AND TREATMENT OF SUBACUTE SEVERE HEPATITIS / 第二军医大学学报

ABSTRACT

In an attempt to find out an effective treatment for severe hepatitis, clinical characteristics and treatment of fifty cases of subacute severe hepatitis (subacute necrosis of the liver), admitted to our department, were investigated. The data suggested that (l)the fatality rate was significantly higher in the aged(40 years) group; (2) the five clinical features such as fever, exudative ascites, prolonged prothrombin time, negative CIC and increased peripheral white cell count (10?109 /L) significantly indicated a poor prognosis; (3) multiorgans system failure (MOSF)was found to be more common (71.9%) in this group- (4) branched chain amino acid (B.CAA) therapy benefited and revived most of the cases, however, did not rescue their life eventually.Fetal liver cell transplantation (iv) survived 4 out of 6 treated patients (66. 7%)without any side-effects, so it seems to be a hopeful therapeutic strategy in this field. This report also emphasizes that the mechanism of subrxute severe hepatitis and antiviral agents in its treatment remained to be studied