EFFECTS OF QUINIDINE, DAURICINE & TETRANDRINE ON REPERFUSION-INDUCED ARRHYTHMIAS IN THE RATS / 中国药理学通报

ABSTRACT

Five min coronary artery occlusion followed by reperfusion in rats could produce arrhythmias which were rapid in onset & of short duration. The incidences of VT & VF being 100% & 72% respectively. Quinidine & dauricine reduced the incidence & severity of VT significantly; and abolished VF. Tetrandrine could reduce the incidence of VF significantly, but it had no significant effect on the incidence of VT.