Ubiquitin Ligases in Cholesterol Metabolism
Diabetes & Metabolism Journal
;
: 171-180, 2014.
Artículo
en Inglés
| WPRIM
| ID: wpr-55009
ABSTRACT
To maintain cholesterol homeostasis, the processes of cholesterol metabolism are regulated at multiple levels including transcription, translation, and enzymatic activity. Recently, the regulation of protein stability of some key players in cholesterol metabolism has been characterized. More and more ubiquitin ligases have been identified including gp78, Hrd1, TRC8, TEB4, Fbw7, and inducible degrader of low density lipoprotein receptor. Their working mechanisms and physiological functions are becoming revealed. Here, we summarize the structure, substrates and function of these ubiquitin ligases. Their potential application in drug discovery is also discussed.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Receptores de LDL
/
Colesterol
/
Ubiquitina
/
Descubrimiento de Drogas
/
Estabilidad Proteica
/
Homeostasis
/
Ligasas
/
Metabolismo
Idioma:
Inglés
Revista:
Diabetes & Metabolism Journal
Año:
2014
Tipo del documento:
Artículo
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