EFFECTS OF GINSENOSIDES ON THE ACTIVITIES OF Na~+, K~+-ATPase OF DOG HEART SARCOLEMMA / 中国药理学通报
Chinese Pharmacological Bulletin
; (12)1987.
Article
en Zh
| WPRIM
| ID: wpr-550155
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WPRO
ABSTRACT
The effects of ginsenosides(including the total ginsenoside extracted from stems and leaves-GNS, ginsenoside extracted from rots-GRS, panaxadiol saPonin-PDS and panaxatriol saponin-PTS) on the activities of Na+, K+-ATPase of dog heart sarcolemma were studied in vivo and in vitro.Both GNS and GRS showed dramatic inhibitory effects on the activities of Na+, K+-ATPase at 10, 20 and 40 mg/kg .The activities of Na+, K+-ATPase were also significantly inhibited by PDS and PTS at 5, 10 and 20 mg/kg. In vitro, all the ginsenosides used in this experiment, at the concentrations of 0.01, 0.10 and 1.00 g/L, Possessed significant inhibitory effects on the activities of dog heart sarcolemmal Na+, K+-ATPase .These results indicated that the enhancement of the contractility of cardiac muscle by ginsenosides is associated with its inhibition on the activities of Na+, K+-ATPase .
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Idioma:
Zh
Revista:
Chinese Pharmacological Bulletin
Año:
1987
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Article