Synthesis and Antithrombotic Effect of CI-930 / 第二军医大学学报
Academic Journal of Second Military Medical University
;
(12)1982.
Artículo
en Chino
| WPRIM
| ID: wpr-550211
ABSTRACT
A novel cardiotonic CJ-930 was successfully designed and synthesized with a new synthetic route. The method and reactive condition on acylating, hydrolytic and condensating reaction were also improved.In addition to convenience of operation, a new synthetic route showed also the advantage over Sircar's method on the raising of total yield 26% to 36%.This compound significantly inhibited the in vitro aggregation of rabbit platelet induced by arachidonic acid, U46619, collagen, ADP and platelet activating factor(PAF). In rabbit or rat platelet, CI-930 depressed the synthesis of thromboxane A.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Academic Journal of Second Military Medical University
Año:
1982
Tipo del documento:
Artículo
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