THE EFFECT OF TETRAMETHYLPYRAZINE ANTITHROMBIN ON AGGREGATION BETWEEN MONONUCLEARCYTES AND PLATELETS / 中国药理学通报

ABSTRACT

Thrombin-induced aggregation between mononuclearcytes and platelets was investigated and shown to be calcium dependent. Tetrame-thylpyrazine inhibited the aggregation and a dose-effect relationship was demonstrated. Tetramethylpyrazine also prevented the decrease of blood leukocyte count induced with thrombin venous injection in mice. Angelica sinensis Diels and tanshinone did not show any obvious effects on thrombin-induced aggregation between mononuclearcytes and platelets.