A PRELIMINARY STUDY ON THE METHOD OF RADIANT HEAT INDUCED PAIN AND ITS VALIDITY IN THE CLINICAL ASSESSMENT OF ANALGESIC DRUGS / 中国药理学通报

ABSTRACT

The basic pain threshold and pain tolerance were measured by use of radiant heat stimulation in healthy volunteers, which were close to normal distribution. The stability was obtained by repeated determination for same individuals in different time. With this method, a clinical assessment of analgesic drugs was carried out among healthy volunteers. Acetaminophen-Codeine tablet ( 2 tablets ) was able to depress pain response by increasing pain threshold and tolerance of 23% and 12% ( P