EFFECTS OF NAPHTHYLMETHYL ISOQUINOLINE ON CONTRACTILE TENSION AND VOLUME OF OXYGEN CONSUMPTION IN HEART MUSCLES / 中国药理学通报
Chinese Pharmacological Bulletin
; (12)1987.
Article
en Zh
| WPRIM
| ID: wpr-550483
Biblioteca responsable:
WPRO
ABSTRACT
The effects of naphthylmethyl isoquinoline (NI) and verapamil (Ver) on contractile tension and volume of oxygen consumption were compared on isolated guinea pig left atrips and cat papillary muscles. The results showed that NI and Ver diminished the Ca++-dependent contractile tension and volume of oxygen consumption by electrically driven preparations. Under the influence of increasing doses of NI (10 ~100?mol/L)and Ver(0.72~3.6?mol/L) linear reduction of contractile tension and volume of oxygen consumption were seen. These effects were reversed by increasing the extracellular Ca++ concentration. These results indicate that NI may be an effective calcium-antagonist very similar to Ver.
Texto completo:
1
Índice:
WPRIM
Idioma:
Zh
Revista:
Chinese Pharmacological Bulletin
Año:
1987
Tipo del documento:
Article