EFFECTS OF FLAVONES OF CHOEROSPONDIAS AXILLARIS FRUCTUS ON IMMUNOLOGICAL FUNCTION IN MICE / 中国药理学通报

ABSTRACT

Total flavones were isolated from the fructus of choerospon-dias axillaris(Roxb. )Burrt et Hill ( TFC ) . TFC (40.32 and 20.16 nig/kg?d-1 , ip~5d) strengthened markedly functions of cellulae immunity and humoral immunity in normal mice as well as in immunodepressed mice induced by cyclophsphamide ( 25mg/kg?d-l, ih~2d). TFC caused a significant increase of the weights of spleen and thy-mus, and the production of serum hymolysin in normal and immunodepressed mice.TFC elevated normal titer of antibody induced by secondary antigen stimulation, and increased ANAE ( + ) cell percentage of lymphocyte and phagocytic activity of macrophages of abdominal cavity in normal and immunodepressed mice. TFC increaced the production of serum lysozyme in normal mice.