CHANGES IN VITAMIN E AND ITS RELATIONSHIP TO LIPID PEROXIDATION AFTER BURNS / 营养学报

ABSTRACT

The values of vitamin E in serum were decreased significantly in rats with 15% BSA III burn from 1.5 hours to 7 days postburn, and then restored gradually, while the levels of lipid peroxides in serum and lung were increased from 1.5 hours to 3 days. The activities of superoxide dismutase and glutathine peroxidase in blood were also decreased after burns, the former remaining low within 14 days and the latter restoring after 7 days postburn. After intraperitoneal injection of vitamin E to the burned rats, the overproduction of lipid peroxides in serum and lung was inhibited with inhibition rates of 28% and 31%, respectively. No more pathological changes of ultrastructural picture were observed in lung of the burned rats supplemented with vitamin E as compared to the control. The results showed that it was beneficial to supply vitamin E in treatment of burns as soon as possible.