INHIBITORY EFFECTS OF ACTINOMYCIN 23-21 ON TRANSPLANTED TUMORS OF HUMAN NASOPHARYNGEAL CARCINOMATOUS CELLS AND GASTRIC CARCINOMATOUS CELLS IN NUDE MICE / 中国药理学通报

ABSTRACT

Actinomycin 23-21 ( ACT 23-21 ) is an anticancer antibiotic of Actinmycines. This antibiotic was produced from soil Streptomyces flaveolus which was isolated and obtained from soil samples in Fuzhou, China.The effects of ACT 23-21 were observed on using 2 transplanted models of human nasophryangeal carcinomatous cells ( CNE-2Z ) and human gastric carcinomatous cells ( MGc-803 ) in nude mice. At ACT 23-21 50?g/kg, the inhibition rate for transplanted tumors of CNE-2Z and MGc-803 were 58.4% (P