Glycated ?-Lipoprotein: An Indicator of Diabedc Vascular Complications / 第二军医大学学报

ABSTRACT

We described a simple method for determining glycated lipoproteins (glc Lps) in serum by agarose gel film electrophoresis, and color development with nitroblue tetrazolium. The resulting blue bands on the film were measured densitometrically at 545 nm to quantify ?-, pre-?-, and ?-glc Lps. The concentration of gfc ?-Lp in serum from diabetics was 2,2-fold higher than that in normal individuals. Diabetic patients with vascular complications had higher concentrations of glc ?-Lp than did patients without vascular complication. The concentration of glc ?-Lp (glc LDL) in serum may be a useful diagnostic indicator of diabetic vascular complications and their severity.