Increased Interleukin-17 Expression in Patients with Idiopathic Inflammatory Myopathies / 대한류마티스학회지
The Journal of the Korean Rheumatism Association
;
: 118-122, 2008.
Artículo
en Coreano
| WPRIM
| ID: wpr-55108
ABSTRACT
OBJECTIVE:
Idiopathic inflammatory myopathies (IIMs) are systemic autoimmune diseases characterized by infiltration of T lymphocytes, monocytes, and macrophages in muscle tissues. Interleukin-17 (IL-17), a Th17 cytokine, has potent pro-inflammatory actions and plays a role in autoimmune diseases. We investigated the expression of IL-17 in muscle tissues of patients with IIMs.METHODS:
We measured the IL-17 mRNA level of muscle tissues from 14 patients with IIMs (9 patients with dermatomyositis and 5 patients with polymyositis) by real-time RT-PCR and compared with controls. We also performed an immunohistochemical stain to detect IL-17 expression.RESULTS:
The expressions of IL-17 were significantly enhanced in IIMs than controls. In immunohistochemistry, IL-17 was expressed in perimysial, endomysial and perivascular infiltrating inflammatory cells.CONCLUSION:
These results suggest that IL-17 plays a role in the immunopathogenesis of IIMs.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Coreano
Revista:
The Journal of the Korean Rheumatism Association
Año:
2008
Tipo del documento:
Artículo
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