The role of nitric oxide and nitric oxide synthase in killing tumor cells / 第二军医大学学报
Academic Journal of Second Military Medical University
;
(12)1999.
Artículo
en Chino
| WPRIM
| ID: wpr-551647
ABSTRACT
Objective:
To study the role of inducible nitric oxide synthase (iNOS) in activated macrophages and nitric oxide (NO) in the defence against tumors.Methods:
Macrophages were obtained by alveolar lavages of mice and activated through incubation with recombinant murine INF? in vitro. P815 cells were added to the culture. Culture supernates were collected to measure the activity of iNOS and NO. Tumoricidal activity of macrophages was determined in presence and absence of the specific inhibitor of NO synthase L NMMA.Results:
NO production and activity of iNOS induced by activated macrophages were positively related with concentration of INF? in macrophage P815 coculture. The addition of L NMMA to the culture suppressed NO production, the inhibitory rate of activated macrophages against P815 cells was reduced distinctly ( P
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Academic Journal of Second Military Medical University
Año:
1999
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS