Protective effects of polydatin on mouse hepatocyte injury induced by hydrogen peroxide in vitro / 中国药理学通报
Chinese Pharmacological Bulletin
;
(12)1986.
Artículo
en Chino
| WPRIM
| ID: wpr-551703
ABSTRACT
AIM To investigate the effects of polydatin on mouse hepatocyte injury induced by hydrogen peroxide(H 2O 2). METHODS Mouse hepatocytes were prepared. SOD activity, MDA content, GSH level, GSH-px activity, glutamic-pyruvic transaminase (ALT), nitric oxide(NO) and nitric oxide synthase(NOS) were determined with different method, respectively. RESULTS After 1 h incubation, the mouse hepatocytes with various concentrations of polydatin (0 05, 0 1, 0 5, 1, 2, 4 mmol?L -1 ), significantly decreased the contents of NO and MDA, inhibited the NOS activity, increased the activities of SOD and GSH-px, suppressed the consumption of GSH, and reduced the elevated ALT level in the supernatant induced by H 2O 2. CONCLUSION Polydatin can protect hepatocytes from oxidative injury induced by H 2O 2.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Pharmacological Bulletin
Año:
1986
Tipo del documento:
Artículo
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