Obstructive Ventilatory Impairment as a Risk Factor of Lung Cancer / 결핵
Tuberculosis and Respiratory Diseases
;
: 746-753, 1998.
Artículo
en Coreano
| WPRIM
| ID: wpr-55200
ABSTRACT
BACKGROUND:
Cigarette smoking is closely related to both lung cancer and chronic obstructive pulmonary disease. The incidence of lung cancer is higher in patients with obstructive ventilatory impairment than in patients without obstructive ventilatory impairment regardless of smoking. So, obstructive ventilatory impairment is suspected as an independent risk factor of lung cancer.METHODS:
For the evaluation of the role of obstructive ventilatory impairment as a risk factor of lung cancer, a total of 73 cases comprising 47 cases of malignant and 26 benign solitary pulmonary nodule were analyzed retrospectively. A comparative study of analysis of forced expiratory volume curves and frequencies of obstructive ventilatory impairment were made between cases with malignant and benign nodules.RESULTS:
In comparison of vital capacity and parameters derived from forced expiratory volume curve between two groups, VC, FVC and FEV1 were not significantly different whereas FEV1/FVC% and FEF 25-75 % showed a significant decrease in the cases with malignant nodule. The frequency of obstructive ventilatory impairment determined by pulmonary function test was significantly higher in the cases with malignant nodule (23.4%) than in benign nodule(3.8%). When the risk for lung cancer was examined by the presence or absence of obstructive ventilatory impairment using the logistic regression analysis, the unadjusted relative risk for the lung cancer of obstructive ventilatory impairment was 17.17. When the effect of smoking and age were considered, the relative risk was to 8.13. CONCLUISON These findings suggest that an obstructive ventilatory impairment is a risk factor of lung cancer.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Pruebas de Función Respiratoria
/
Humo
/
Fumar
/
Modelos Logísticos
/
Capacidad Vital
/
Volumen Espiratorio Forzado
/
Incidencia
/
Estudios Retrospectivos
/
Factores de Riesgo
/
Nódulo Pulmonar Solitario
Tipo de estudio:
Estudio de etiología
/
Estudio de incidencia
/
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Humanos
Idioma:
Coreano
Revista:
Tuberculosis and Respiratory Diseases
Año:
1998
Tipo del documento:
Artículo
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