THE PROTECTIVE EFFECT OF TAKEPRON ON THE GASTRIC MUCOSAL LESION IN RATS AND ITS MECHANISMS / 解放军医学杂志

ABSTRACT

To observe the protective effect of takepron(lansoprazole)on the gastric mucosal lesion in rats and its mechanisms . Before gastric mucosal lesion was produced in rats with pure alcohol,takepron was administered into the gastric lumen, and N? nitro L arginine methyl ester(L NAME) and L arginine were injected intravenously. Gastric mucosal blood flow(GMBF)was assessed with laser Doppler flowmetry,gastric mucosal and serum NO - 2 /NO - 3 were measured by cadmium granulation reduction and colorimetric method,and the gastric mucosal ulcer index(UI),the degree of tissue necrosis and neutrophil infiltration were observed . The results showed that UI of the takepron group was much lower than that of the control group( P