EFFECT OF RECOMBINANT HUMAN INTERLECUKIN-11(rhIL-11)ON PERIPHERAL PLATELET COUNT AND HEMATOPOIETIC PROGENITOR PROLIFERATION / 解放军医学杂志

ABSTRACT

In order to obtain experimental evidences of therapeutic effect of rhIL 11 for clinical use, we observed the effects of rhIL 11 on colony formation of multilineage human hematopoietic cells in vitro and acceleration of platelet count and bone marrow hematopoietic recovery in 3 0Gy ? ray irradiated rhesus monkeys. The results showed that rhIL 11 significantly increased the nadirs of PLT count and shortened the duration of PLT numbers below 50% of their baseline values. The recovery of PLT in irradiated monkeys was accelerated. Dosage related PLT recovery was not observed. rhIL 11 not only promoted the proliferation and maturation of CFU Mk but also improved the proliferation of CFU GM, CFU e, BFU e and CFU Mix. These data suggest that rhIL 11 may be an effective agent in the treatment of hemopoietic suppression and thrombocytopenia.