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CHARACTERISTICS AND CLINICAL IMPLICATION OF HIV-1 CORECEPTOR CX_3CR1 ALLELIC POLYMORPHISM IN UIGUR ETHNIC GROUP FROM SINKIANG UIGUR AUTONOMOUS REGION / 解放军医学杂志
Medical Journal of Chinese People's Liberation Army ; (12)1982.
Artículo en Chino | WPRIM | ID: wpr-552644
ABSTRACT
It was reported that 249I 280M haplotype of HIV coreceptor CX 3 CR1 was associated with accelerated AIDS progression. In this study, genomic DNA of 119 Uigur subjects (98 normal, 21 HIV 1 infected) was purified from PBMC, and 249I and 280M allelic frequencies were identified by PCR RFLP. All data were tested by ? 2 analysis.It was found that allelic frequency of 249I and 280M was 15 8% and 13 8%, respectively, and there was no difference between normal and HIV infected groups. Both population and sex distribution were in accordance with Hardy Weinberg equilibrium. Frequency of 249I280M haplotype was 13 8%, close to that of Caucasian people. No linkage was found between CX 3 CR1 and CCR5?32, but strong linkage existed between 249I and 280M ( P

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Tipo de estudio: Estudio pronóstico Idioma: Chino Revista: Medical Journal of Chinese People's Liberation Army Año: 1982 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Tipo de estudio: Estudio pronóstico Idioma: Chino Revista: Medical Journal of Chinese People's Liberation Army Año: 1982 Tipo del documento: Artículo