Gamma knife treatment of pituitary adenoma: a report of 145 cases / 第三军医大学学报

ABSTRACT

Objective To study and assess the therapeutic efficacy of Gamma knife on pituitary adenoma. Methods An analysis of 145 cases with pituitary adenoma treated by Gamma knife in our department in the past 4 years was performed. Adenoma diameter varied from 2.8 to 46.9 mm, averaging 15.6mm. In all cases, 4 mm and 8 mm isocenters were targeted at pituitary adenoma located by MRI and ? plan network. The target margin dose varied from 8 to 36 Gy, averaging 22.7 Gy (nonfunctioning adenomas, 18.5 Gy; functioning adenomas, 24.1 Gy). Results The follow up of 124 cases after radiosurgery varied from 6 to 56 months. Pituitary adenoma of 24 patients(19.4%) disappeared, 95 (76.6%) decreased, and 1 (76.6%) increased. Endocrinological normalization rate was 13 cases (13.3%), and a significant decrease of excessive hormone production was found in 71 patients (72.4%). Amelioration of clinical symptom was found in 114 patients (91.9%), deterioration in 4 patients (3.2%). Postradiosurgical complications were found in 2.4%. Neither optical lesion nor death was found in all cases. Conclusions Gamma knife radiosurgery is a minimally invasive technique to treat pituitary adenoma with satisfactory therapeutic efficacy. It is associated with a low risk of complication. Grasping adaptive sign strictly and planning precisely are needed to decrease complication.