EFFECT OF PENTOXIFYLLINE ON THE EXPRESSIONS OF SEVERAL INFLAMMATORY CYTOKINE GENES IN RATS WITH SEPSIS-INDUCED ACUTE LUNG INJUR / 解放军医学杂志

ABSTRACT

To investigate the expression of TNF ?, IL 1?, IL 6 and IL 8 mRNA in the lung,and the levels of TNF ?, IL 1, IL 6 and IL 8 in serum of rats with sepsis induced acute lung injury(ALI), and to examine the effect of pentoxifylline on the production of these cytokines. The expressions of TNF ?, IL 1?, IL 6 and IL 8 mRNA were detected with dot blot.The levels of TNF ?, IL 1?, IL 6 and IL 8 were examined with ELISA. Compared to the sham operation group, TNF ?, IL 1?, IL 6 and IL 8 mRNA expression in sepsis group were increased evidently( P