Study on superantigen SEC against glioma / 中国药理学通报

ABSTRACT

AIM To probe into antitumor effect of lymphocyte activated by superantigen SEC against glioma. METHODS Lymphocyte subset was analysed with APAAP method after the lymphocyte had been activated by SEC. The cytotoxicity of lymphocyte against glioma in vitro was evaluated by MTT method. With established animal model of glioma xenografted and immunity embeded model of HuPBL-SCID, we observed the growth of glioma. RESULTS The lymphocyte activated was mainly composed of CD4 + T lymphocyte. Lymphocyte activated by SEC had killing activety against 8 glioma cells and the group of 1?10 3 U?L -1 had shown the strongest killing power. The growth curve showed thateach of the rate of producing A, C and B group different suppress effect on glioma its suppress rate was 58.5%,46.2% and 36.3% respectively. CONCLUSION Lymphocyte stimulated by superantigen SEC produces killing power against glioma.