Comparison of energy metabolism on brain lacking oxygen between Salvia miltiorrhiza Bunge injection and Salvia przewalskii Maxim injection in mice / 中国临床药理学与治疗学

ABSTRACT

AIM: To compare the influence of salvia miltiorrhiza Bunge njection (SMBI) and salvia przewalskii Maxim injec tion (SPMI) on energy metabolism of acute brain lacking oxygen. METHODS: The whole brain lacking oxygen model was made by injecting NaNO 2 in mice and then wrote down the existent time of mice and detected the contents of Na +-K +-ATPase, Ca 2+ -ATPase and lactic acid (LD) in the brain. RESULTS: SMBI and SPMI both significantly lengthened the existent tim e of mice with the whole brain lacking oxygen, decreased the contents of LD and increased the activity of ATPase in mice. In increasing the activity of ATPase, the influence of SPMI was more than that of SMBI (P 0.05 ). CONCLUSION: SMBI an d SPMI have distinctive protection on energy metabolism of acute brain lacking o xygen. Both of them can lengthen the existent of mice, reduce the contents of LD in brain and increase the activity of ATPase, but SPMI is more excellent than S MBI in increasing the activity of ATPase.