Antidepressant Effects of Ketamine on Depression-like Behavior in Juvenile Mice after Neonatal Dexamethasone Exposure
Clinical Psychopharmacology and Neuroscience
;
: 124-127, 2014.
Artículo
en Inglés
| WPRIM
| ID: wpr-55549
ABSTRACT
OBJECTIVE:
Pediatric depression is associated with significant functional impairment at school and at work. Recently, we reported on depression-like behavior in juvenile mice neonatally exposed to dexamethasone (DEX) as a potential animal model for pediatric depression. The N-methyl-D-aspartate (NMDA) receptor antagonist ketamine has promoted rapid and long-lasting antidepressant effects in patients with treatment-resistant major depression. This study was conducted to examine whether ketamine had antidepressant effects in juvenile mice after neonatal DEX exposure.METHODS:
A single dose (10 mg/kg) of ketamine or vehicle was injected into juvenile mice at days 29-32 after neonatal DEX (or saline) exposure (days 1-3). The sucrose preference test, tail suspension test, and forced swimming test were performed 24, 40, and 46 hours, respectively, after injection of ketamine.RESULTS:
Ketamine (10 mg/kg) significantly improved depression-like behavior in DEX-treated juvenile mice.CONCLUSION:
This finding suggests that ketamine confers antidepressant effects in an animal model of pediatric depression.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Sacarosa
/
Dexametasona
/
N-Metilaspartato
/
Receptores de N-Metil-D-Aspartato
/
Suspensión Trasera
/
Modelos Animales
/
Depresión
/
Esfuerzo Físico
/
Ketamina
/
Antidepresivos
Límite:
Animales
/
Humanos
Idioma:
Inglés
Revista:
Clinical Psychopharmacology and Neuroscience
Año:
2014
Tipo del documento:
Artículo
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