Effect of skin condition on the permeability of theophylline via rat skin / 中国药理学通报

ABSTRACT

Aim To investigate the influence of skin layers ( st ratum corneum and viable layer) on the percutaneous absorption of drug with or w ithout isopropyl myristate (IPM). Methods We chose theophylline (TP ) as a model drug. Patches containing saturated concentration of TP were prepare d. The in vitrotransdermal permeation experiment via different rat skin lay ers was carried out. Results The Kp of TP via stripped skin was 2.1 times larger than that via intact skin. The permea bility was en hanced when coexisted with IPM either via intact skin or via stripped skin. Conclusion IPM can significantly enhance the percutaneous absorption of TP via different skin layers. And these data and methods represent a novel appr oach to evaluate the effects of skin damage and skin disease on drug percutaneou s absorption.