GPCR-G? fusion protein and its applications on ligand screening of orphan G protein-coupled receptors / 中国药理学通报
Chinese Pharmacological Bulletin
;
(12)1986.
Artículo
en Chino
| WPRIM
| ID: wpr-556612
ABSTRACT
GPCR-G alpha fusion protein has been used to investig ate receptors in recent years. The expression of GPCR-G alpha fusion protein en sured defined 1∶1 stoichiometry, the physical proximity of GPCR to G alpha subu nit, and was suitable for high-throughput ligand screening. The fusion protein technology provided a novel strategy to study orphan GPCRs. Obviously, it will p lay important roles in ligand screening of the orphan GPCRs and exert its signif icances in the R&D of novel drugs targeted at oGPCRs.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Tipo de estudio:
Estudio diagnóstico
/
Estudio de tamizaje
Idioma:
Chino
Revista:
Chinese Pharmacological Bulletin
Año:
1986
Tipo del documento:
Artículo
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