The karyotype and clinical analysis of 30 cases with Turner syndrome / 中国实用内科杂志

ABSTRACT

Objective To research on and analyze the relationship between the clinical situation and karyotype of 30 patients with Turner syndrome (TS).Methods Lymphocytes of peripheral blood were cultured,then karyotyped by G banding and R banding technique.The relationship between clinical situation and karyotype of patients with TS were analyzed.Results The karyotype of TS could be divided into 4 groups45,XO;mosaicism;with aberration of X chromosome structure and with Y chromosome.The mosaicism was the most popular.The more abnormal karyotype was,the more typical sexual non-development.Conclusion The typical patients with TS had the clinical features of microsomia,menoschesis,sexual non-development and special somatotype.The different clinical features are decided by the degree of abnormal karyotype and the proportion between abnormal cells and normal cells.Besides,the patients with TS who have Y chromosome always show hemaphrodism and must be taken ganadectomy.