Loss of heterozigosity of nm23-H_1 gene might induce lymph node metastasis in no-small-cell lung cancer / 第三军医大学学报
Journal of Third Military Medical University
; (24)2002.
Article
en Zh
| WPRIM
| ID: wpr-556785
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WPRO
ABSTRACT
Objective To explore the relationship between the loss of the heterozygosity of nm23-H_1 and the lymph node metastasis in no-small-cell lung cancer (NSCLC). Methods The loss of the heterozygosity of nm23-H_1 gene of cancer tissue and peri-cancerous tissue was detected in 39 patients with NSCLC by Southern blotting. Results The heterozygosity gene of nm23-H_1 is 7.6 kb and 2.3 kb. The LOH rate of the patients with lymph node metastasis (48%, 12/25) was higher than those without lymph node involvement (8%, 1/11) (P
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Idioma:
Zh
Revista:
Journal of Third Military Medical University
Año:
2002
Tipo del documento:
Article