Indomethacin suppresses matrix metalloproteinase-9 expression in abdominal aortic aneurysm in rats / 第二军医大学学报
Academic Journal of Second Military Medical University
;
(12)1985.
Artículo
en Chino
| WPRIM
| ID: wpr-556810
ABSTRACT
Objective:
To investigate the mechanism by which indomethacin inhibits the expression of matrix metalloproteinase-9 in abdominal aortic aneurysm(AAA) in rats.Methods:
Male Wistar rats underwent intraluminal perfusion of the abdominal aorta with 50 units of porcine pancreatic elastase followed by treatment with indomethacin (1.6 mg/d) subcutaneously (n=8) for 7 d or with normal saline(NS,n=8).Aortic wall elastin and collagen concentrations were measured with an imaging analysis system, and fixed aortic tissues were examined by light microscopy for inflammation. The expression of MMP-9 in aortic tissues was observed with immunohistochemistry technique.Results:
AAAs developed in all NS treated rats and in none of indomethacin treated rats on d 7(P
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Academic Journal of Second Military Medical University
Año:
1985
Tipo del documento:
Artículo
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