Effects of sodium nitroprusside on glutamate-induced responses of supraoptic nucleus neurons in vitro / 中国药理学通报

ABSTRACT

Aim To realize the modulatory actions of nitric oxide(NO) on supraoptic nucleus(SON)neurons by observing the effects of NO donor sodium nitroprusside(SNP) on the SON neurons. Methods The cell electrophysiology properties were obtained by the intracellular recording techniques from the SON neurons in adult rat hypothalamic slices. Results Local pressure ejection of glutamate induced depolarizing responses with decrease of input resistance, concentration- and membrane potential-dependent properties in 12 SON neurons. The amplitude and duration of glutamate responses were suppressed by bath of SNP in 67% of tested cells(P