Study on the effect of cpd Danshen tablet combined with vitamin E in chronic hepatitis B(CHB)-related liver fibrosis / 中国实用内科杂志

ABSTRACT

Objective To probe the effect of Cpd danshen tablet combined with vitamin E in liver fibrosis by chronic hepatitis B.Methods 44 patients with CHB-related live fibrosis were allocated randomly into control group and Cpd danshen tablet combined with vitamin E treatment group for 6 months' treatment.Serum ALT,AST level and fibrosis markers including hyaluronic acid (HA),Ⅳ collagen(Ⅳ-C),amino terminal propeptide of type Ⅲ procollagen (PⅢP),and laminin(LN) and serum MMP1,2,TIMP1,2 level were determined before and after 6 months.Liver biopsies before and after 6 months were assessed.Results ALT,AST level in the two groups were decreased after 6 months' treatment(.P.