Drug-resistance of bacteria and application of antibacterial agents in spontaneous bacterial peritonitis / 解放军医学杂志

ABSTRACT

Objective To investigate the distribution of the bacteria in ascites of spontaneous bacterial peritonitis (SBP), and to find out the resistance of the bacteria to antibacterial agents. Methods 44 inpatients from 1999 to 2003 with SBP and positive bacterial culture in ascites were selected, and the bacterial distribution, resistance to drugs and the application of antibacterial agents were analyzed. Results 88.6% (39/44) of the 44 isolations were gram-negative bacillus, among them 28 isolations were E. coli. The results of drug sensitive test revealed that 90% of E. coli, Aeromonas sobria, Klebsiella pneumoniae were sensitive to the third generation of cephalosporin. The resistant rate of E. coli to cefotriaxone and cefotaxime were 11.54% and 12.50%, respectively. Conclusion The third generation of cephalosporin was the experiential selection in treating SBP before getting the report of drug sensitive test. Anti-bacterial agents combined with ?-lactamase inhibitors may be used in treating some severe cases.