Your browser doesn't support javascript.
loading
Effects of isoproterenol on myocardial fibrosis and related cytokines in rats / 中国临床药理学与治疗学
Article en Zh | WPRIM | ID: wpr-557401
Biblioteca responsable: WPRO
ABSTRACT
AIM:To study the effects of isoproterenol (Iso) on cardiac fibrosis and related cytokines in rats. METHODS:20 SD rats were divided into control and Iso group in random, with 10 rats each group. After injected Iso, cardiac histology was observed and cardiac function, collagen volume fraction (CVF), content of collagen protein and the concentrations of Angiotensin Ⅱ (Angll) and nitrogen monoxide (NO) were measured in the two groups. RESULTS:Compared with control group, microscopic examination showed that fibrosis increased in Iso group. Iso did decrease cardiac function and NO levels and increase CVF, content of collagen protein and AngII levels. Left ventricular pressure maximal rate of rise (+ dp/dt_(max)) and left ventricular systolic pressure (LVSP) were not significantly different from that of control group. CONCLUSIONS:Iso can induce myocardial fibrosis and change levels of related cytokines in rats.
Palabras clave
Texto completo: 1 Índice: WPRIM Idioma: Zh Revista: Chinese Journal of Clinical Pharmacology and Therapeutics Año: 2004 Tipo del documento: Article
Texto completo: 1 Índice: WPRIM Idioma: Zh Revista: Chinese Journal of Clinical Pharmacology and Therapeutics Año: 2004 Tipo del documento: Article