Study on viral pathogen of acute respiratory infection in 741 children / 第三军医大学学报

ABSTRACT

Objective To study the difference between season, respiratory disease,age and sex in viral pathogens of acute respiratory infection(ARI) of children in Chongqing during 2003-2004 to provide strategy for clinical treatment and precaution.Methods Nasopharyngeal secretion was obtained from 741 in-patient children diagnosed as ARI,and respiratory syncytial virus(RSV),para influenza virus Ⅰ,Ⅱ,Ⅲ,adenovirus and influenza virus A,B were detected by direct immunofluorescence.Results There was relationship between total positive rate of virus pathogens of children's ARI and season,respiratory disease and age,but not for sex.Positive rate of virus was highest in winter,bronchiolitis and infants aged 29 days-6 months,lowest in spring,upper respiratory infection and children over 3 years.Among the 7 virus,top detected virus was RSV(positive rate was 87.3%),followed in turn by para influenza virus Ⅲ,adenovirus,influenza virus A.There was highest RSV detection rate in infants aged 0-6 months with bronchiolitis,and lowest in children over 3 years with upper respiratory infection.Adenovirus was commonly detected in summer,and girls over 3 years with upper respiratory infection,and influenza virus A commonly in summer and children with upper respiratory infection(URI).Conclusion Detection of viral pathogens in children with respiratory infection could give fast,accurate diagnostic evidence, and help avoid antibiotics abuse.Viral kinds could be estimated by epidemiologic features such as season,disease and age etc.Antiviral antibody and other detection should be done if necessary for facilitating the treatment and precaution of ARI.