Experimental Study on Effects of Jiangzhi Tongmai Fang on Inhibiting Hyperlipemia and Atherosclerosis / 中华中医药杂志

ABSTRACT

Objective: To observe the therapeutic effect and possible mechanism of Jiangzhi Tongmai Fang(JZTMF) on preventing and curing atherosclerosis with methods of invigorating the spleen,dispersing phlegm and dissolving blood stasis.Methods: C57/BL-ApoE knock out mice were raised with cholesterol animal feeds for 90 days to form the experimental models of hypercholesterolemia and atherosclerotic plaque.At the same time the TCM group was given complex prescription of Chinese materia medica continuously for 90 days.The plasma Level of triglyceride(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C) and high density lipoprotein cholesterol(HDL-C) were measured by the end of experiment.Light microscope was adopted to assess the degree of pathologic damage of arterial wall.Results: Complex prescription of Chinese materia medica JZTMF with methods of invigorating the spleen,dispersing phlegm and dissolving blood stasis could inhibit the upgrade of plasma TC,LDL-C.Conclusion: JZTMF could cure experimental hyperlipemia and inhibit the formation of atherosclerotic plaques.