The expression and role of ERK and JNK in cerebral ischemic preconditioning in gerbil / 中国药理学通报
Chinese Pharmacological Bulletin
;
(12)1987.
Artículo
en Chino
| WPRIM
| ID: wpr-558381
ABSTRACT
Aim To explore the expression and role of ERK and JNK in cerebral ischemic preconditioning in gerbil.Methods Forebrain ischemia was induced by occlusion of bilateral carotid arteries.Gerbils were randomly divided into sham group(SH),ischemic-preconditioning control group(IC),ischemic-preconditioning group(IP),ischemia-reperfusion group(IR).The gerbils were killed in 15 min,2,4,6 h,1,3,5 and 7 d in each group following reperfusion.Open field test was used to examine the behavioral deficit in the due time.The number of surviving and apoptosis neurons in hippocampal CA1/3 region was counted,and the activity of p-ERK and p-JNK in hippocampus was detected using SP immunocytochemical technique.Results The behavioral mark and the number of apoptosis neurons in hippocampal CA1 region in group IP were much less than that in group IR(P
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Pharmacological Bulletin
Año:
1987
Tipo del documento:
Artículo
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