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Changes in the expression of cytokines and apoptosis-related genes in children with infectious mononucleosis / 소아과
Korean Journal of Pediatrics ; : 1348-1357, 2009.
Artículo en Coreano | WPRIM | ID: wpr-55861
ABSTRACT

PURPOSE:

The aims of this study were to identify the clinical characteristics and determine the changes in the expression of cytokines and apoptosis-related genes in children with infectious mononucleosis.

METHODS:

Serological examinations of 15 pediatric patients diagnosed with infectious mononucleosis were performed prospectively. Peripheral blood from the patients was used to compare the composition of T cell subsets, cytokines, Epstein-Barr virus (EBV) DNA, and the expression of apoptosis-related genes with those in 10 healthy children.

RESULTS:

Mean age of the patient group was 5.7+/-3.4 (range, 3-9) years, and the male-to-female ratio was 1.51. Fever, sore throat, pharyngitis/tonsillitis, and cervical lymph node enlargement were the most common symptoms and signs. The proportions of CD3+ T cells, CD8+ suppressor cells, and CD56+ natural killer (NK) cells were higher in the patient group than in the control group (P<0.01). The IL-2, IL-6, and interferon (IFN)-gamma levels were higher in the early symptomatic period (P<0.01). Mean amount of EBV DNA in the patients was 10(2.38) copies/microg, and the amount was the highest at the beginning of the symptomatic period and normalized during the convalescent phase. Bcl-2 expression increased during the initial phase, while Bax expression increased during the convalescent phase. Further, FasL expression increased 1 week after symptom presentation and decreased during the convalescent phase. There was no significant change in Fas expression.

CONCLUSION:

We analyzed the clinical characteristics and changes in the expression ofcytokines and apoptosis-related genes in the patients with infectious mononucleosis.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: ADN / Linfocitos T / Faringitis / Estudios Prospectivos / Citocinas / Subgrupos de Linfocitos T / Interferones / Interleucina-6 / Interleucina-2 / Apoptosis Tipo de estudio: Estudio observacional / Estudio pronóstico Límite: Niño / Humanos Idioma: Coreano Revista: Korean Journal of Pediatrics Año: 2009 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: ADN / Linfocitos T / Faringitis / Estudios Prospectivos / Citocinas / Subgrupos de Linfocitos T / Interferones / Interleucina-6 / Interleucina-2 / Apoptosis Tipo de estudio: Estudio observacional / Estudio pronóstico Límite: Niño / Humanos Idioma: Coreano Revista: Korean Journal of Pediatrics Año: 2009 Tipo del documento: Artículo