Effect of icariin on expression of cytochrome C oxidase subunit Ⅱ mRNA in mice of cerebral ischemia/reperfusion / 第三军医大学学报
Journal of Third Military Medical University
; (24)2003.
Article
en Zh
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| ID: wpr-558619
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WPRO
ABSTRACT
Objective To evaluate the effects of cerebral ischemia/reperfusion or/and icariin on expression of cytochrome C oxidase subunitⅡ(COⅡ) mRNA in mice. Methods The mouse model of transient cerebral ischemia/reperfusion was made by bilateral occlusion of common carotid arteries and ischemic hypotension/reperfusion. The mice were divided into several groups at random: normal control group, model group and icariin preventive treatment group (100 mg/kg). The changes in expression levels of COⅡ mRNA in mice cerebral tissue were detected by RT-PCR at different time points. Results The levels of CO Ⅱ mRNA in model group had no significant changes at 1 h and 24 h after cerebral ischemia/reperfusion as compared with that in control group, but decreased remarkably at 3 h (P
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Zh
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Journal of Third Military Medical University
Año:
2003
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Article