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Cyclosporine 0.05% Ophthalmic Emulsion for Dry Eye in Korea: A Prospective, Multicenter, Open-Label, Surveillance Study
Korean Journal of Ophthalmology ; : 369-374, 2011.
Artículo en Inglés | WPRIM | ID: wpr-55888
ABSTRACT

PURPOSE:

To assess the effectiveness and tolerability of cyclosporine ophthalmic emulsion (CsA) 0.05% in patients with moderate to severe dry eye disease in Korea.

METHODS:

This was a prospective, multicenter, open-label, surveillance study of 392 Korean patients with moderate to severe dry eye disease who were treated with CsA 0.05% for three months. An assessment of effectiveness was performed at baseline, and after 1, 2, and 3 months. The primary effectiveness outcomes were changes in ocular symptoms and Schirmer score. The secondary effectiveness outcomes were a change in conjunctival staining, use of artificial tears, global evaluation of treatment, and patient satisfaction. The primary safety outcome was the incidence and nature of adverse events.

RESULTS:

A total of 362 patients completed the study. After three months, all ocular symptom scores were significantly reduced compared to the baseline values, while the Schirmer scores were significantly increased relative to baseline (p 50%) experienced at least a 25% to 50% improvement in symptoms from baseline at each follow-up visit. The majority of patients (72.0%) were satisfied with the treatment results, and 57.2% reported having no or mild symptoms after treatment. The most common adverse events were ocular pain (11.0%).

CONCLUSIONS:

Our findings indicate that CsA 0.05% is an effective and tolerable treatment for dry eye disease in Korean clinical practice.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Síndromes de Ojo Seco / Vigilancia de la Población / Estudios Prospectivos / Estudios de Seguimiento / Resultado del Tratamiento / Ciclosporina / Emulsiones / República de Corea / Inmunosupresores Tipo de estudio: Ensayo Clínico Controlado / Estudio observacional / Estudio pronóstico / Factores de riesgo / Estudio de tamizaje Límite: Femenino / Humanos / Masculino País/Región como asunto: Asia Idioma: Inglés Revista: Korean Journal of Ophthalmology Año: 2011 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Síndromes de Ojo Seco / Vigilancia de la Población / Estudios Prospectivos / Estudios de Seguimiento / Resultado del Tratamiento / Ciclosporina / Emulsiones / República de Corea / Inmunosupresores Tipo de estudio: Ensayo Clínico Controlado / Estudio observacional / Estudio pronóstico / Factores de riesgo / Estudio de tamizaje Límite: Femenino / Humanos / Masculino País/Región como asunto: Asia Idioma: Inglés Revista: Korean Journal of Ophthalmology Año: 2011 Tipo del documento: Artículo