STUDY ON THE SENSIBILITY OF LPL-PVUⅡ GENE POLYMORPHISM TO INTERVENTION OF COARSE GRAIN FOOD IN DYSLIPIDEMIA POPULATION / 营养学报
Acta Nutrimenta Sinica
;
(6)1956.
Artículo
en Chino
| WPRIM
| ID: wpr-559301
ABSTRACT
Objective:
To explore the different genotypes’ susceptibility to intervention of coarse grain food in dyslipdemia population.Method:
409 middle and old aged residents with blood lipoprotein abnormalities were randomized to 2 groups the intervention group (230 subjects) and the control group (179 subjects). Everyone of the former group was given a steamed bread of coarse grain food per day and health education once every month; while the control group was only given health education. Intervention period was 6 months. The genotypes of LPL-Pvu Ⅱ of the intervention group were analyzed by PCR-RFLP (restriction fragment length polymorphism) technique.Results:
All indices in intervention group except WHR were improved after intervention. BMI, WHR, SBP, DBP, serum TG were significantly lower than control group; while serum HDL-C was significantly higher than control group after intervention. Among all genotype groups, the P+/P+ group was more sensible for the change of serum TG and more significant in the effect of improving blood lipids than the P-/P- group; and the susceptibility of change for TC and HDL-C in serum was least in the P-/P- group.Conclusion:
There are good intervention effects of coarse grain food in dyslipdemia population. The susceptibilities to improve blood lipids vary with different geno-types of LPL-Pvu Ⅱ , especially for change of serum TG ,and P+/P+ group was more sensible.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Tipo de estudio:
Ensayo Clínico Controlado
Idioma:
Chino
Revista:
Acta Nutrimenta Sinica
Año:
1956
Tipo del documento:
Artículo
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