Neutrophil elastase: a target of neuroprotection / 中国药理学通报

ABSTRACT

Tissue or organic injuries(especially induced by ischemia/reperfusion) are often followed by inflammatory response characterized with neutrophil infiltration.Neutrophils exacerbate tissue or organic injuries by releasing elastase.Since brain injuries induced by cerebral ischemia/reperfusion,intracerebral hemorrhage,cerebral trauma also accompany infiltration of neutrophil,and elastase derived from neutrophil probably plays an important role in brain injury.