Effects of LPS on development of atherosclerosis and role of TLR4 / 第三军医大学学报

ABSTRACT

Objective To investigate the effects of chronic inflammation, induced by LPS on the development of rat aorta atherosclerosis. Methods Eighty healthy male Wistar rats were divided into 4 groups, normal control, the endotoxin group, homofat-breeded group and endotoxin-homofat-breeded group. HE staining was used to detect the change of rat aorta endomembrane and immunohistochemistry was used to detect the change of expression of TLR4 in rat aorta endothelial cell. Results The AS animal model was constructed successfully and the expression of TLR4 was at a higher level in endotoxin-homofat-breeded group than that in other groups. Conclusion Chronic inflammation has an actively effect during the development of rat aorta atherosclerosis.