Effects of celecoxib on the expression of PGE2 and VEGF A549 cell lines / 中国实用内科杂志
Chinese Journal of Practical Internal Medicine
;
(12)2001.
Artículo
en Chino
| WPRIM
| ID: wpr-560914
ABSTRACT
Objective To investigate the effect of the selective cyclooxygenase-2 inhibitor celecoxib on the expression of PGE2 and VEGF induced by IL-1? in A549 cell lines.Methods A549 cells were incubated with IL-1? in the presence or absence of celecoxib.After indicated incubation time,cells were harvested to detect VEGFmRNA by reverse transcription-polymerase chain rection(RT-PCR),the medium was collected to determine the concentration of PGE2 and VEGF by enzyme-linked immunosorbent assay(ELISA).Results After Celecoxib intervention,the formation of PGE2 and VEGF expression decreased more than control group(IL-1? induced),the difference being significance(P
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Journal of Practical Internal Medicine
Año:
2001
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS