EEG alterations and conscious state of epileptic rats during absence seizure induced by pentylenetetrazol / 第三军医大学学报

ABSTRACT

Objective To evaluate whether the pentylenetetrazol(PTZ)model is an appropriate animal model of absence seizure.Methods A series of tests including EEG,active avoidance response(AAR)and passive escape response(PER)in a two-way shuttle box were finished during seizure induced by PTZ(35 mg/kg,ip)in 40 Wistar epileptic rats.Results Epileptiform activity was characterized by bilaterally spike wave discharges synchronously elicited during seizure in PTZ models.During absence seizure induced by PTZ,the latency of active avoidance response was significantly prolonged.AAR positive rate was decreased by 85%.PER positive rate was increased by 56%,and escape failure positive rate was increased by 29%.Conclusion There is epileptiform discharge accompanying transient conscious disturbance during absence seizure induced by pentylenetetrazol.