Effect of arterial baroreflex on survival rate of rats with cecal ligation and puncture-induced sepsis / 第二军医大学学报
Academic Journal of Second Military Medical University
;
(12)2000.
Artículo
en Chino
| WPRIM
| ID: wpr-561859
ABSTRACT
Objective:
To investigate the effect of arterial baroreflex(ABR)on survival rate of rats with cecal ligation and puncture(CLP)-induced sepsis.Methods:
Male Sprague-Dawley rats were divided into 2 groupssham-operated rats(n=22)and sinoaortic denervated(SAD)rats(n=22).Four weeks after SAD rats were subjected to CLP-induced sepsis,the blood pressure and heart period(HP)were monitored for 12 hours in conscious state and the survival of rats was observed.Results:
Both the diastolic and systolic blood pressue gradually decreased after CLP;the HP shortened first and then drastically prolonged until the death of rats.At 12 h after CLP the survival rate of SAD rats was lower than that of the sham-operated rats(59% vs 86%).Significant differences were found between the Kaplan-Meier survival curves of the rats in 2 groups(P
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Academic Journal of Second Military Medical University
Año:
2000
Tipo del documento:
Artículo
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