Analgesis comparision of morphine administration intravenously and epidurally combined with bupivacaine in postoperative children / 中国临床药理学与治疗学

ABSTRACT

AIM:To compare the analgesic efficacy and safety of intravenous morphine or epidural morphine combined with bupivacaine in postoperative children.METHODS:48 children scheduled for selective inferior belly or lower limb surgery under general anaesthesia or epidural anesthesia for ASA I or II,age from 3 to 10 years old,were randomly divided into 3 groups(n=16 each).Group A was given intravenous morphine for postoperative analgesia,group B was given epidural morphine in combination with bupivacaine,group C was given nonsteroidal anti-inflammatory drugs orally or pethidine intramuscularly in need as the control group.When the patients were fully awake in the recovery area,heart rate(HR),blood pressure,peripheral oxygen saturation(SpO2),respiratory rate and pain were recorded at 2,4,8,12,24 and 48 h postoperatively,side-effects were also noted.Pain was assessed using an objective pain score(OPS).RESULTS:There was no significant difference of OPS between group A and B,and the efficacy and duration of analgesia in group A and B were significantly better than those in group C(P